Santa Fe is not served by the Metro, so the only ways into the area are by car, taxi or bus. Cars and taxis are probably the fastest, but are certainly not the cheapest. However, Santa Fe is served by Mexico City's RTP network and much more frequently by pesero buses, which leave from Tacubaya station Metro Lines 1, 7 and 9 and take around 30-45 minutes to get there. Look for buses that say "Sta. Fe" in the window.
You will recognize instantly when you are in Santa Fe, when the two-lane road widens to lessen stop-and-go traffic and grand office buildings replace stucco shanties. If you're on a pesero, it will travel around the skyscrapers rather than go inbetween them; a good place to get off and look around is when the bus is on Avenida Vasco de Quiroga, or on the opposite end of the line of skyscrapers. Don't wait too long though, because the bus continues onward into the residential area of the hills.
